As befits the child of a scientist, Martin Picard's young son, 3, is already learning about biology with an age-appropriate textbook, 'Cell Biology for Babies.' Picard winces a little whenever the book calls mitochondria the 'powerhouses of the cell' but figures he has plenty of time as his son grows older to explain why the tiny organelles are much more than simple energy sources.
, Picard's team found that stress can alter the activity of the brain's mitochondria and predict subsequent anxiety-like and social behaviors in mice. But not all brain mitochondria had the same impact. Only changes in a specific network of mitochondria, mostly in the cortex and striatum, correlated with anxiety while other networks of mitochondria showed no to little connection with behaviors.
Other research in people conducted by Picard and collaborators at UCSF suggests that positive feelings may have effects on mitochondria that improve health. In, emotions people felt on Tuesday nights influenced the energy transformation capacity of mitochondria in blood immune cells measured on Wednesdays. The study provided the first directional evidence that mood may affect mitochondria.
During a short break after college, one of his mentors—a mitochondrial biologist—persuaded him to join her lab by giving him the freedom to pursue outside interests, be it cycling or integrative medicine. Picard's doctoral thesis focused on the role of mitochondria in aging, yet he also carved out time to study systems biology and psychosocial oncology.
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