STOCKHOLM, Oct 2 — Hungarian scientist Katalin Kariko and US colleague Drew Weissman, who met in line for a photocopier before making mRNA molecule discoveries that paved the way...
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Kariko, a former senior vice president and head of RNA protein replacement at German biotech firm BioNTech, is a professor at the University of Szeged in Hungary and adjunct professor at the University of Pennsylvania. The two laureates in 2005 jointly developed so-called nucleoside base modifications, which stop the immune system from launching an inflammatory attack against lab-made mRNA, previously seen as a major hurdle against any therapeutic use of the technology.
At the University of Pennsylvania, she tried to turn mRNA into a treatment tool throughout the 1990s but struggled to win grants because work on DNA and gene therapy captured most of the scientific community’s attention at the time. “It is absolutely right that the ground-breaking work on RNA led by Kariko and Weissman should be recognised by a Nobel Prize,” said Sir Andrew Pollard, an immunology professor at Oxford University, who pursued a different technology when co-developing the lesser-used Covid vaccine by AstraZeneca .
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